Skip to main content

Full Schedule

Full Schedule

  • Wednesday, July 10, 2024
  • PLENARY SESSION - 9:30 AM WEDNESDAY
  • 9:30 AM – 11:30 AM CEST
    PLENARY I: PRESIDENTIAL SYMPOSIUM
    The Presidential Symposium aims to showcase cutting-edge research from global leaders in the field of tissue stem cells, pluripotent stem cells, stem cell genomics and machine learning.

    Speakers
    Magdalena Goetz, PhD, Helmholtz Zentrum Muenchen, Germany
    Tina Mukherjee, PhD, Institute of Stem Cell Science and Regenerative Medicine (inStem), India
    Kathrin Plath, PhD, University of California Los Angeles School of Medicine, USA
    Sarah Teichmann, Wellcome Sanger Institute, UK
  • INNOVATION SHOWCASES - 12:00 PM WEDNESDAY
  • 12:00 PM – 12:30 PM CEST
    IMPROVING THE GENETIC STABILITY OF SINGLE-CELL-PASSAGED HUMAN PLURIPOTENT STEM CELL CULTURES USING eTeSR™
    In this talk, we’ll discuss new genetic stability data on cultures maintained in eTeSR™, a novel human pluripotent stem cell (hPSC) maintenance medium, specifically developed to support routine single-cell passaging. The study comprises over 250 SNP microarray samples collected from clones derived using three hPSC lines and maintained for 20 weeks in four media conditions. The study shows that clones maintained in eTeSR™ acquire fewer de novo cytogenetic changes compared to two alternative, commercially available maintenance media. This improvement in genetic stability can be attributed to the absence of 20q11 gains in eTeSR™-maintained cultures, a recurrent abnormality that has been well-documented in hPSC cultures. This study provides a better understanding of culture-acquired genetic aberrations in hPSCs and demonstrates that innovative media formulations such as eTeSR™ can address major challenges in the hPSC field.

    Innovation Showcase

  • 12:00 PM – 1:00 PM CEST
    GENETIC WHACK-A-MOLE: BATTLING INSTABILITIES IN iPSCS
    With the ability to differentiate into all body tissue types and the potential for commercial scale manufacture, human induced Pluripotent Stem Cells (iPSCs) are an ideal starting material for the next generation of cellular therapeutics. However, inconsistency in the culture process can predispose cells to genetic abnormalities that can influence growth rate and differentiation efficiency. Persistence of these genetic alternations in the final product can introduce a safety risk to patients receiving these life altering therapies. Detecting genetic abnormalities is difficult, as no single assay can cover all potential alterations and may be at low levels that are below the detection limit of some assays. A combination of testing modalities at frequent and predetermined intervals can cover the most common genetic alterations and limit downstream risk. Similarly, culture strategies can be implemented to minimize the rate of de novo mutations and prevent abnormal colonies from overtaking genetically normal variants. This presentation will discuss the challenges of maintaining genetic integrity during the commercial manufacture of iPSCs and propose practical approaches to ensuring that clinical iPSCs are free of mutations for product development.

    Innovation Showcase

  • 12:00 PM – 1:00 PM CEST
    FROM MANUAL TO AUTOMATED: REVOLUTIONIZING HIPSC DIFFERENTIATION BY INCREASING EFFICIENCY AND FIDELITY FOR NPCS, HSCS, AND LPCS, WITH CELLRAFT TECHNOLOGY 
    Unlocking the full potential of patient-derived and genetically modified human induced pluripotent stem cells (hiPSCs) for disease modeling requires precise differentiation protocols. Despite the availability of various protocols and kits, the technical intricacies of hiPSC differentiation often lead to inefficiencies and reproducibility challenges. We aim to address these hurdles by leveraging CellRaft® Technology, offering solutions for hiPSC differentiation workflows. What you will learn: - How to enhance efficiency in hiPSC differentiation - How to automate the monitoring and isolation of neural progenitor cells (NPCs), ensuring high fidelity differentiation - How to improve hematopoietic progenitor cell (HSC) differentiation, leading to enhanced colony survival and yield - How to utilize technology to streamline differentiation by accurately purifying populations, increasing differentiation accuracy Overall, our findings underscore the significance of automating manual steps in hiPSC differentiation, highlighting how image-based monitoring, phenotypic selection, and isolation can enhance efficiency and fidelity, thereby expediting the development of relevant disease models.

    Innovation Showcase

  • 12:30 PM – 1:00 PM CEST
    ISSCR STANDARDS IN ACTION: ADVANCEMENTS IN CELL LINE GENERATION AND ORGANOID INNOVATION
    Join us for an insightful session on our latest advancements in cell line generation, featuring the SCTi003-A and SCTi004-A healthy control iPSC lines. These cell lines represent a significant step forward in the field, aligning with and advancing beyond the established ISSCR guidelines for stem cell research. Our presentation will focus on how these lines are shaping the future of stem cell research, including their central role in various applications and contribution to setting new benchmarks in research quality and ethical standards. We will spotlight iPSCdirect™, our efficient, ready-to-use, singularized iPSC product. Additionally, we will showcase the development of various differentiated types and organoids, including the launch of live, experiment-ready midbrain organoids, designed for immediate application upon delivery to your laboratory. Explore how these cutting-edge technologies are revolutionizing disease modeling, drug discovery, and more, while upholding our commitment to advancing research quality and ethical integrity.

    Innovation Showcase

  • PLENARY SESSION - 1:30 PM WEDNESDAY
  • 1:30 PM – 3:35 PM CEST
    PLENARY II: NEW TECHNOLOGIES TO ENGINEER AND PHENOTYPE STEM CELL SYSTEMS

    Plenary Speaker: Matthias P. Lutolf, PhD – Institute of Human Biology (IHB) F. Hoffmann-La Roche

    Recent technological and analytical advances have made it possible to characterize stem cell systems at an unprecedented resolution. This session highlights emerging single cell and imaging technologies to phenotype stem cells as well as to program or perturb cell fate.

    Speakers
    Matthias Lutolf, PhD, Institute of Human Biology (IHB) F Hoffmann-La Roche, Switzerland
    Susanne Rafelski, PhD, Allen Institute for Cell Science, USA
    Fabian Theis, PhD, Helmholtz Zentrum München, Germany
    Jonathan Weissman, PhD, Whitehead Institute for Biomedical Research, HHMI, MIT, USA

    ISSCR Outstanding Young Investigator Award
    Jun Wu, PhD, University of Texas Southwestern Medical Center, USA

    New Technologies

  • SCIENCE SPOTLIGHT & FOCUS SESSIONS; EDI & CAREER PANEL - 4:00 PM WEDNESDAY
  • 4:00 PM – 5:30 PM CEST
    TRANSLATION OF ACADEMIC RESEARCH: FROM NICE TO HAVE TO CLINICAL IMPERATIVE

    Chair: Ana Hidalgo-Simon, MD, PhD – Leiden University Medical Center

    Speaker: Stefan Irion, MD – BlueRock Therapeutics

    Panelist: Lisa Ott de Bruin, MD, PhD – Leiden University Medical Centre

    Panelist: Melanio Unas Mauricio, III – Leiden University Medical Center

    Speaker: Megan Munsie, PhD (she/her/hers) – University of Melbourne

    Speaker: Chantal van Litsenbrug – Leiden University Medical Center

    Science Spotlight The dynamic field of translational medicine, particularly in the context of cutting-edge cell and gene therapies, is reshaping the role of academic research centers. This session will discuss optimizing the academic research framework for clinical relevance, focusing on regulatory science, accessibility, stakeholder engagement, and organizational optimization. Academic institutions are increasingly pressurized to drive the progression from pre-clinical stages to clinical trials, with the potential to achieve market authorization. With the rising interest in academic drug development and the backdrop of healthcare sustainability challenges, there's a growing shift of public funding towards research collaborations focused on clinical applications. However, institutions often lack the specific capacity, knowledge and focus, which are essential for successfully navigating the entire development pathway to market authorization. The session will explore pivotal areas for researchers in translational medicine, stressing the importance of translatable approaches for research impact. Accessibility, including regulatory navigation and Health Technology Assessment, is vital for successful translation and influences funding and EU legislation debates. Engaging stakeholders strategically is crucial for aligning therapies with clinical goals and patient expectations. Finally, the need for organizational innovation is discussed, highlighting strategies for cross-disciplinary collaboration and rethinking structures to support research's transformation into clinically impactful therapies.

    Science Spotlight

  • 4:00 PM – 5:30 PM CEST
    HARVESTING STEM CELL INNOVATION: THE SYMBIOTIC RELATIONASHIP BETWEEN ACADEMIA AND INDUSTRY IN CULTIVATED MEAT DEVELOPMENT
    Science Spotlight Cultivated meat, an innovative cellular agriculture method, addresses climate change, resource scarcity, and a growing population. It transforms animal stem cells into a sustainable nutrition source, countering challenges in traditional livestock farming. With the global population surpassing 8 billion, conventional methods are insufficient. Cultivated meat offers a solution, ensuring a diverse and secure supply of high-quality animal products while minimizing the environmental impact. Despite the advances of this new chapter of animal agriculture, the field encounters multi-faceted challenges. These encompass fundamental research areas such as comprehensive stem cell characterization, improving differentiation processes, growth media and bioprocessing optimization, and improved tissue engineering methods. Moreover, scalability and cost-effectiveness pose significant hurdles in achieving widespread adoption and commercial viability. Therefore, ongoing research is vital to drive innovations to enhance the prospects of cultivated meat for future advancements. This session explores the science of cultivated meat and cellular agriculture, presenting diverse research from academic labs and the cultivated meat industry. Hear insights from academic leaders, trainees, industry experts, and non-profit organizations, fostering a dynamic exchange of knowledge and expertise on grant funding, career opportunities, and collaborative research translations between academia and industry for transformative advancements.

    Science Spotlight

  • 4:00 PM – 5:30 PM CEST
    FRONTIERS IN EPIGENETIC GENE EDITING OF STEM CELLS
    Science Spotlight Our symposium, "Frontiers in Epigenetic Gene Editing of Stem Cells," will explore the latest advancements and methodologies in the field. It will delve into the successes and challenges of manipulating the epigenome to direct stem cell fate and function. The session will highlight the progress being made engineering therapeutically relevant cells as wells, discussing the utility of epigenetic programming to understand basic development mechanisms.

    Science Spotlight

  • 4:00 PM – 5:30 PM CEST
    EXPLORING BIOPHYSICAL CUES: UNRAVELING MECHANOTRANSDUCTION IN PLURIPOTENT STEM CELL DIRECTED DIFFERENTIATION

    Co-Chair: Dana Brinson – University of Toronto

    Co-Chair: Golnaz Karoubi – University Health Network

    Speaker: Sara Wickström, MD, PhD – Max Planck Institute for Molecular Biomedicine

    Speaker: Claudia Loebel, MD, PhD – University of Michigan

    Science Spotlight This session will explore the interplay between biophysical cues and pluripotent stem cell differentiation. Participants will hear about current progress in leveraging the mechanical microenvironment to improve the fidelity of stem cell-derived tissues. Recent advancements in our understanding of how Mechan transduction directs cell fate via epigenomic changes will be discussed, providing a comprehensive update on the current state of knowledge in this emerging subject.

    Science Spotlight

  • 4:00 PM – 5:30 PM CEST
    TOOLS FOR BASIC AND APPLIED STEM CELL BIOLOGY

    Chair: Tenneille Ludwig, PhD – WiCell Research Institute

    Speaker: Laurent David, PhD – Universite de Nantes

    Speaker: Camille Tempier Lemey, PhD – STEMCELL Technologies

    Speaker: Dmitry A. Ovchinnikov, PhD – Florey Institute / University of Melbourne

    Speaker: Grazia Iannello, PhD – Columbia University

    Speaker: Sebastian Diecke, PhD – Max Delbruck Center for Molecular Medicine

    Speaker: Sarah Perez Munoz, PhD – Thermo Fisher Scientific

    Organized by COREdinates Supported by STEMCELL Technologies and Thermo Fisher Scientific Stem Cell COREdinates (www.COREdinates.org) is an international consortium of human pluripotent stem cell-focused core facilities that share expertise with protocols, reagents, and technological advancements to establish “best practices" in the maintenance, derivation, differentiation and genetic manipulation of human pluripotent stem cells. Each of our member cores plays an important role in the research and educational missions of their respective institutions. The Focus Session will have selected presentations from Stem Cell COREdinate members and our sponsors. These presentations will cover a number of different areas of expertise including stem cell characterization, gene editing and disease modeling.This session will benefit stem cell researchers who are just starting to use pluripotent stem cell tools in their own laboratories and experienced researchers who are seeking to expand their toolbox. These presentations from the COREdinate members will cover a variety of topics that will have direct impact on improving workflow, establishing new technology and advancing existing methodology.

    Focus Session

  • 4:00 PM – 5:30 PM CEST
    EQUITY, DIVERSITY, AND INCLUSION IN THE DISH

    Panelist: Brian Aguado, PhD – University of California San Diego

    Panelist: Ralda Nehme – Broad Institute of Harvard and MIT and Harvard University

    Stem cells offer significant potential to unravel disease mechanisms, inform novel medicines, and develop innovative cell therapies for challenging medical conditions. However, there is a growing appreciation that a “one size fits all” approach to research and therapies is not applicable to all individuals. Biases in stem cell sourcing have exacerbated disparities in our understanding of how genetic ancestry impacts stem cell phenotypes. Specifically, genetic background is rarely considered as a biological variable for in vitro disease models, despite the significant influence that biological variables such as sex or ancestry have on overall cell phenotypes, including maintenance of pluripotency, differentiation tendencies, and responses to developmental signals. The primary objective of this session is to highlight current practices for diversifying biological samples in the lab and leveraging diversity in stem cell research. This session will also define plans to improve the accessibility of stem cell therapies through financial considerations, global access, and policy/ethics considerations.

    Ethics, Policy and Standards

  • 4:00 PM – 5:30 PM CEST
    CAREER PLURIPOTENCY: PIONEERING PATHS IN ACADEMIC AND NON-ACADEMIC SECTORS

    Moderator: Thomas Hutschalik, MSc (he/him/his) – Ncardia Services B.V.

    Panelist: Marie Obien, PhD – MaxWell Biosystems

    Panelist: Melissa Carpenter, PhD – Carpenter Consulting Corporation

    Panelist: Giuliana Gagliardi

    Panelist: Tina Mukherjee, PhD (she/her/hers) – Institute for Stem Cell Science and Regenerative Medicine (inStem)

    Career Panel If you find yourself caught up in the excitement yet daunted by the rapid evolution in stem cell research, join our career panel this year. In this session, we will bring together a diverse group of experts to explore the dynamic landscape of stem cell scientists and to discuss the evolving career opportunities in this field. Our panelists will share their professional trajectories, discuss both academic and non-academic paths in stem cell science, and provide insights for young scientists on how to navigate their own journey. Join us for an exciting session that aims to empower you to thrive in the face of career uncertainty.

    Panel

  • POSTER SESSIONS & EXHIBIT HALL EVENTS - 5:45 PM WEDNESDAY
  • 5:45 PM – 7:45 PM CEST
    POSTER SESSIONS and EXHIBIT HALL EVENTS
    Join us for these events in the Poster and Exhibit Hall:

    5:45 PM – 7:30 PM OPENING RECEPTION
    Supported by AMSBIO, bit.bio, Qkine, Science Advances/AAAS, and WiCell

    5:45 PM- 6:45PM POSTERSESSION I: ODD

    6:45 PM – 7:45 PM POSTER SESSION I: EVEN

    EXHIBIT HALL THEATER TALKS
    Bite-sized, 15-minute sessions on specialized topics. Pop in and out of the Exhibit Hall Theater to catch these brief presentations from scientific and industry leaders. Talks will be given by Beijing SeekGene BioSciences Co.,Ltd, Eppendorf, Paratus Sciences, Stem Genomics, Union Biometrica.
    Schedules to be announced.

    MEET-UP HUBS
    Join your colleagues and engage in conversation and networking at these common interest discussion forums.
    Schedules to be announced.