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Full Schedule

  • Saturday, July 13, 2024
  • CONCURRENT TRACK AND FOCUS SESSIONS - 8:15 AM SATURDAY
  • 8:15 AM – 9:45 AM CEST
    IDENTIFYING THE ETHICAL COMPLEXITIES AND GOVERNANCE IMPLICATIONS FOR EMBRYO MODEL RESEARCH

    Moderator: Kazuto Kato, PhD – Osaka University

    Concurrent Speaker: Rosario Isasi, JD, MPH (she/her/hers) – University of Miami

    Concurrent Speaker: Hongmei Wang, PhD – Institute of Zoology, Chinese Academy of Sciences

    Concurrent Speaker: Søren Holm, PhD, MD, DrMed (he/him/his) – University of Manchester

    Concurrent Speaker: Sandy Starr – Progress Educational Trust (PET)

    Research with stem cell-based embryo models has opened new avenues for studying embryogenesis and its implications to understanding human disorders and diseases. However, science is advancing so rapidly that jurisdictions around the world are struggling with the evolving ethical complexities and boundaries of exploration. This session pulls together experts grappling with the implications of these developments to help us understand the scientific landscape and formulate coherent regulations based on robust ethical and governance discussions around the globe.

    Ethics, Policy and Standards

  • 8:15 AM – 9:45 AM CEST
    UPDATES ON CLINICAL TRIALS

    Co-Chair: Ganna Bilousova, PhD (she/her/hers) – University of Colorado Anschutz Medical Campus

    Co-Chair: Roger Barker, MRCP PhD – University of Cambridge

    Concurrent Speaker: Viviane Tabar, MD – Memorial Sloan Kettering Cancer Center

    Presenting Author: Ruchi Sharma – NEI/NIH

    Presenting Author: Lisa Ott de Bruin, MD, PhD – Leiden University Medical Centre

    Presenting Author: Hideyuki Okano, MD, PhD (he/him/his) – Keio University

    Presenting Author: Sonja Schrepfer, MD, PhD – Sana Biotechnology

    This session will provide a high-level overview of regenerative medicine efforts by institution and/or organ.

    Clinical Applications

  • 8:15 AM – 9:45 AM CEST
    THE USE OF STEM CELLS IN DISEASE MODELING II

    Co-Chair: Jeffrey Beekman, PhD – University Medical Center Utrecht

    Co-Chair: David Elliott – MCRI

    Concurrent Speaker: Ryuji Morizane, MD, PhD (he/him/his) – Massachusetts General Hospital

    Presenting Author: Jubao Duan – University of Chicago/NorthShore University HelathSystem

    Presenting Author: Carmen Menacho – Heinrich Heine University Düsseldorf

    Presenting Author: Gunnar Hargus, MD, PhD – Columbia University

    Presenting Author: Giovanni Pietrogrande, PhD – The University of Queensland

    Concurrent Speaker: Guo-li Ming, MD, PhD (she/her/hers) – University of Pennsylvania

    Many stem cell models now exist for multiple genetic diseases. They are increasingly used for finding therapeutics. Examples of how stem cell models are being used for drug discovery will be shown in this session.

    Disease Modeling and Drug Discovery

  • 8:15 AM – 9:45 AM CEST
    ENGINEERING APPROACHES TO DEVELOPMENTAL AND STEM CELL BIOLOGY

    Chair: Filipe Pereira, PhD (he/him/his) – Lund University

    Concurrent Speaker: Miki Ebisuya, PhD (she/her/hers) – Physics of Life TU Dresden

    Presenting Author: Jianping Fu, PhD – University of Michigan, Ann Arbor

    Presenting Author: Connor C. Fausto – University of Southern California

    Presenting Author: Sveva Bottini, MSci – University of Torino

    Presenting Author: Suzan Stelloo, PhD – RIMLS, Radboud University

    Concurrent Speaker: Ron Weiss, PhD – MIT

    Stem cells sense their environment, process information, and continuously react to stimuli to self-renew or differentiate. In this session, speakers will cover the construction of synthetic gene networks as well as new models of human developmental mechanisms to improve our understanding of stem cell regulatory networks.

    New Technologies

  • 8:15 AM – 9:45 AM CEST
    TISSUE AND ORGAN DEVELOPMENT

    Co-Chair: Miguel Esteban, PhD – Guangzhou Institutes of Biomedicine and Health

    Co-Chair: Mo R. Ebrahimkhani, MD (he/him/his) – University of Pittsburgh

    Concurrent Speaker: Anne Grapin-Botton, PhD – Max Planck Institute of Molecular Cell Biology and Genetics

    Presenting Author: Wolfram Goessling, MD, PhD – Harvard Medical School/Mass General Hospital

    Presenting Author: Yanbo Yin – University of Cambridge

    Presenting Author: Julia Batki, PhD – Max Planck Institute for Molecular Genetics

    Presenting Author: Juan R. Alvarez, PhD – University of Pennsylvania

    Concurrent Speaker: Shahragim Tajbakhsh, PhD – Pasteur Institute

    This session will explore topics of tissue and organ development primarily through the lens of developmental studies in organisms.

    Pluripotency and Development

  • 8:15 AM – 9:45 AM CEST
    CELLULAR PLASTICITY IN REGENERATION AND CANCER

    Co-Chair: Bon-Kyoung Koo, PhD – Institute of Molecular Biotechnology (IMBA), Austria and Center for Genome Engineering, Institute for Basic Science

    Concurrent Speaker: Elisa Laurenti, PhD (she/her/hers) – University of Cambridge

    Presenting Author: Mark Schmitt, PhD – University of Marburg

    Presenting Author: Swarnabh Bhattacharya, PhD – Dana-Farber Cancer Institute/Harvard Medical School

    Presenting Author: Sandra Gomez Lopez – University College London

    Presenting Author: Anupama Hemalatha, PhD – Yale School of Medicine

    Concurrent Speaker: Peter W. Reddien, PhD – Whitehead Institute MIT

    Cell fate transitions, once thought to be irrevocable, are now known to frequently exhibit plasticity. Remarkably, even some terminally differentiated cells can regain the capacity to self-renew when challenged. This session will explore the nature of plasticity in cell fate decisions, pinpoint the contexts in which plasticity is invoked, and dissect its molecular and signaling basis.

    Somatic Stem Cells, Cancer and Regeneration

  • 8:15 AM – 9:45 AM CEST
    INSIGHTS FROM REGULATORS: LESSONS LEARNED FROM THE ISSCR’S REGULATORY LIAISON MEETINGS

    Focus Session Speaker: Jennifer Moody, PhD – Danaher

    Focus Session Speaker: Tenneille Ludwig, PhD – WiCell Research Institute

    Focus Session Speaker: Jacqueline Barry, PhD – Cell and Gene Therapy Catapult

    Focus Session Speaker: Nissim Benvenisty, MD, PhD – The Hebrew University

    Focus Session Speaker: Derek Hei, PhD – Kenai Therapeutics

    Focus Session Speaker: Kapil Bharti, PhD – National Eye Institute; National Center for Advancing Translational Sciences, National Institutes of Health

    Organized by: ISSCR Industry Committee
    Human Pluripotent Stem Cell (hPSC)-derived cell therapies are now being investigated in clinical trials. Despite 26 years of rigorous basic science with hPSCs, navigating the regulatory landscape for the clinical translation of PSC-derived cell therapies remains challenging due to the complexities of cellular drug products and limited experiences reviewing and approving them. As the leading stem cell society, the ISSCR is in a unique position to share its scientific expertise with global regulators and work with agencies to facilitate improved future regulatory processes for stem cell-based therapies. In this ISSCR Industry Focus Session, the society shares important insights and feedback gleaned from its liaison meetings with regulatory agencies with our community of scientists to ameliorate their chances of IND approvals and inform the development of effective and safe new therapies.

    Focus Session

  • PLENARY SESSION - 10:00 AM SATURDAY
  • 10:00 AM – 11:35 AM CEST
    PLENARY VI: THE CLINICAL REALITY AND PROMISE OF CELL AND GENE THERAPIES

    Co-Chair: Roger Barker, MRCP PhD – University of Cambridge

    Co-Chair: Marinna Madrid, PhD – Cellino

    Plenary Speaker: Catherine Priest, PhD (she/her/hers) – Neurona Therapeutics

    Plenary Speaker: Robert P. Coppes, PhD (he/him/his) – University Medical Center Groningen

    Plenary Speaker: Cristiana F. Pires, PharmD, PhD – Asgard Therapeutics

    Speaker: Mikael Rydberg – Patient Advocate

    Plenary Speaker: Michael Lai, PhD (he/him/his) – HeartWorks

    Hear from invited speakers from the various realms of regenerative medicine: ESC- and iPSC-derived cell therapies, gene therapies, and in situ reprogramming.

    Clinical Applications

  • PLENARY SESSION - 1:30 PM SATURDAY
  • 1:30 PM – 3:35 PM CEST
    PLENARY VII: AWARDS & KEYNOTE SESSION

    Co-Chair: Malin Parmar, PhD – Lund University

    Co-Chair: Agnete Kirkeby, PhD – Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, University of Copenhagen

    Speaker: Valentina Greco, PhD – Yale School of Medicine, Genetics Department & Yale Stem Cell Center

    Award Acceptance: Peter W. Andrews, BSc, DPhil, MBA – University of Sheffield

    Award Acceptance: Tenneille Ludwig, PhD – WiCell Research Institute

    Award Winner: Sergiu P. Pașca, PhD – Stanford University

    Award Winner: Fiona M. Watt, DPhil FRS PhD – EMBL-Heidelberg, Germany

    Keynote Speaker: Melissa H. Little, AC, PhD – Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Denmark, and Murdoch Children’s Research Institute, Australia

    This session is the capstone of the Annual Meeting and will include the Public Service Award presentation and lectures from the winners of the ISSCR Momentum and Achievement Awards, in addition to the Keynote Address.

    ISSCR Public Service Award
    Peter W. Andrews, BSc, DPhil, MBA, University of Sheffield, UK
    Tenneille E. Ludwig, PhD, WiCell Stem Cell Bank, USA

    ISSCR Momentum Award Lecture
    Sergiu Paşca, PhD, Stanford University, USA

    ISSCR Achievement Award Lecture
    Fiona M. Watt, DPhil, FRS, EMBL -Heidelberg, Germany

    Melissa H. Little, AC, PhD, Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Denmark, and Murdoch Children’s Research Institute, Australia