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Saturday, July 13, 2024
CONCURRENT TRACK AND FOCUS SESSIONS - 8:15 AM SATURDAY
8:15 AM – 9:45 AM CEST
IDENTIFYING THE ETHICAL COMPLEXITIES AND GOVERNANCE IMPLICATIONS FOR EMBRYO MODEL RESEARCH
Panelist: Hongmei Wang, PhD – Institute of Zoology, Chinese Academy of Sciences
Panelist: Rosario Isasi, JD, MPH (she/her/hers) – University of Miami
Panelist: Søren Holm, PhD, MD, DrMed (he/him/his) – University of Manchester
Panelist: Sandy Starr – Progress Educational Trust (PET)
Research with stem cell-based embryo models has opened new avenues for studying embryogenesis and its implications to understanding human disorders and diseases. However, science is advancing so rapidly that jurisdictions around the world are struggling with the evolving ethical complexities and boundaries of exploration. This session pulls together experts grappling with the implications of these developments to help us understand the scientific landscape and formulate coherent regulations based on robust ethical and governance discussions around the globe.
Ethics, Policy and Standards

8:15 AM – 9:45 AM CEST
UPDATES ON CLINICAL TRIALS
Concurrent Speaker: Viviane Tabar, MD – Memorial Sloan Kettering Cancer Center
Presenting Author: Ruchi Sharma – NEI/NIH
Presenting Author: Lisa Ott de Bruin, MD, PhD – Leiden University Medical Centre
This session will provide a high-level overview of regenerative medicine efforts by institution and/or organ.
Clinical Applications

8:15 AM – 9:45 AM CEST
THE USE OF STEM CELLS IN DISEASE MODELING II
Concurrent Speaker: Ryuji Morizane, MD, PhD (he/him/his) – Massachusetts General Hospital
Concurrent Speaker: Guo-li Ming, MD, PhD (she/her/hers) – University of Pennsylvania
Presenting Author: Jubao Duan – University of Chicago/NorthShore University HelathSystem
Presenting Author: Carmen Menacho – Heinrich Heine University Düsseldorf
Presenting Author: Joel Blanchard, PhD – Icahn School of Medicine at Mount Sinai
Presenting Author: Giovanni Pietrogrande, PhD – The University of Queensland
Many stem cell models now exist for multiple genetic diseases. They are increasingly used for finding therapeutics. Examples of how stem cell models are being used for drug discovery will be shown in this session.
Disease Modeling and Drug Discovery

8:15 AM – 9:45 AM CEST

THE USE OF STEM CELLS IN DISEASE MODELING II

Concurrent Speaker: Ryuji Morizane, MD, PhD (he/him/his) – Massachusetts General Hospital

Concurrent Speaker: Guo-li Ming, MD, PhD (she/her/hers) – University of Pennsylvania

Presenting Author: Jubao Duan – University of Chicago/NorthShore University HelathSystem

Presenting Author: Carmen Menacho – Heinrich Heine University Düsseldorf

Presenting Author: Joel Blanchard, PhD – Icahn School of Medicine at Mount Sinai

Presenting Author: Giovanni Pietrogrande, PhD – The University of Queensland

Many stem cell models now exist for multiple genetic diseases. They are increasingly used for finding therapeutics. Examples of how stem cell models are being used for drug discovery will be shown in this session.

Disease Modeling and Drug Discovery

8:15 AM – 9:45 AM CEST
ENGINEERING APPROACHES TO DEVELOPMENTAL AND STEM CELL BIOLOGY
Concurrent Speaker: Miki Ebisuya, PhD (she/her/hers) – Physics of Life TU Dresden
Concurrent Speaker: Ron Weiss, PhD – MIT
Presenting Author: Jianping Fu, PhD – University of Michigan, Ann Arbor
Presenting Author: Connor C. Fausto – University of Southern California
Presenting Author: Sveva Bottini, MSci – University of Torino
Presenting Author: Suzan Stelloo – RIMLS, Radboud University
Stem cells sense their environment, process information, and continuously react to stimuli to self-renew or differentiate. In this session, speakers will cover the construction of synthetic gene networks as well as new models of human developmental mechanisms to improve our understanding of stem cell regulatory networks.
New Technologies

8:15 AM – 9:45 AM CEST

ENGINEERING APPROACHES TO DEVELOPMENTAL AND STEM CELL BIOLOGY

Concurrent Speaker: Miki Ebisuya, PhD (she/her/hers) – Physics of Life TU Dresden

Concurrent Speaker: Ron Weiss, PhD – MIT

Presenting Author: Jianping Fu, PhD – University of Michigan, Ann Arbor

Presenting Author: Connor C. Fausto – University of Southern California

Presenting Author: Sveva Bottini, MSci – University of Torino

Presenting Author: Suzan Stelloo – RIMLS, Radboud University

Stem cells sense their environment, process information, and continuously react to stimuli to self-renew or differentiate. In this session, speakers will cover the construction of synthetic gene networks as well as new models of human developmental mechanisms to improve our understanding of stem cell regulatory networks.

New Technologies

8:15 AM – 9:45 AM CEST
TISSUE AND ORGAN DEVELOPMENT
Concurrent Speaker: Anne Grapin-Botton, PhD – Max Planck Institute of Molecular Cell Biology and Genetics
Concurrent Speaker: Shahragim Tajbakhsh, PhD – Pasteur Institute
Presenting Author: Wolfram Goessling, MD, PhD – Harvard Medical School/Mass General Hospital
Presenting Author: Yanbo Yin – University of Cambridge
Presenting Author: Julia Batki, PhD – Max Planck Institute for Molecular Genetics
Presenting Author: Juan R. Alvarez, PhD – University of Pennsylvania
This session will explore topics of tissue and organ development primarily through the lens of developmental studies in organisms.
Pluripotency and Development

8:15 AM – 9:45 AM CEST

TISSUE AND ORGAN DEVELOPMENT

Concurrent Speaker: Anne Grapin-Botton, PhD – Max Planck Institute of Molecular Cell Biology and Genetics

Concurrent Speaker: Shahragim Tajbakhsh, PhD – Pasteur Institute

Presenting Author: Wolfram Goessling, MD, PhD – Harvard Medical School/Mass General Hospital

Presenting Author: Yanbo Yin – University of Cambridge

Presenting Author: Julia Batki, PhD – Max Planck Institute for Molecular Genetics

Presenting Author: Juan R. Alvarez, PhD – University of Pennsylvania

This session will explore topics of tissue and organ development primarily through the lens of developmental studies in organisms.

Pluripotency and Development

8:15 AM – 9:45 AM CEST
CELLULAR PLASTICITY IN REGENERATION AND CANCER
Concurrent Speaker: Elisa Laurenti, PhD (she/her/hers) – University of Cambridge
Concurrent Speaker: Peter W. Reddien, PhD – Whitehead Institute MIT
Presenting Author: Mark Schmitt – University of Marburg
Presenting Author: Swarnabh Bhattacharya, PhD – Dana-Farber Cancer Institute/Harvard Medical School
Presenting Author: Sandra Gomez Lopez – University College London
Presenting Author: Anupama Hemalatha, PhD – Yale School of Medicine
Cell fate transitions, once thought to be irrevocable, are now known to frequently exhibit plasticity. Remarkably, even some terminally differentiated cells can regain the capacity to self-renew when challenged. This session will explore the nature of plasticity in cell fate decisions, pinpoint the contexts in which plasticity is invoked, and dissect its molecular and signaling basis.
Somatic Stem Cells, Cancer and Regeneration

8:15 AM – 9:45 AM CEST

CELLULAR PLASTICITY IN REGENERATION AND CANCER

Concurrent Speaker: Elisa Laurenti, PhD (she/her/hers) – University of Cambridge

Concurrent Speaker: Peter W. Reddien, PhD – Whitehead Institute MIT

Presenting Author: Mark Schmitt – University of Marburg

Presenting Author: Swarnabh Bhattacharya, PhD – Dana-Farber Cancer Institute/Harvard Medical School

Presenting Author: Sandra Gomez Lopez – University College London

Presenting Author: Anupama Hemalatha, PhD – Yale School of Medicine

Cell fate transitions, once thought to be irrevocable, are now known to frequently exhibit plasticity. Remarkably, even some terminally differentiated cells can regain the capacity to self-renew when challenged. This session will explore the nature of plasticity in cell fate decisions, pinpoint the contexts in which plasticity is invoked, and dissect its molecular and signaling basis.

Somatic Stem Cells, Cancer and Regeneration

8:15 AM – 9:45 AM CEST
INSIGHTS FROM REGULATORS: LESSONS LEARNED FROM THE ISSCR’S REGULATORY LIAISON MEETINGS
Focus Session Speaker: Jennifer Moody, PhD – Danaher
Focus Session Speaker: Tenneille Ludwig, PhD – WiCell Research Institute
Focus Session Speaker: Jacqueline Barry, PhD – Cell and Gene Therapy Catapult
Focus Session Speaker: Nissim Benvenisty, MD, PhD – The Hebrew University
Focus Session Speaker: Derek Hei, PhD – Clade Therapeutics
Focus Session Speaker: Kapil Bharti, PhD – National Eye Institute; National Center for Advancing Translational Sciences, National Institutes of Health
Organized by: ISSCR Industry Committee
Human Pluripotent Stem Cell (hPSC)-derived cell therapies are now being investigated in clinical trials. Despite 26 years of rigorous basic science with hPSCs, navigating the regulatory landscape for the clinical translation of PSC-derived cell therapies remains challenging due to the complexities of cellular drug products and limited experiences reviewing and approving them. As the leading stem cell society, the ISSCR is in a unique position to share its scientific expertise with global regulators and work with agencies to facilitate improved future regulatory processes for stem cell-based therapies. In this ISSCR Industry Focus Session, the society shares important insights and feedback gleaned from its liaison meetings with regulatory agencies with our community of scientists to ameliorate their chances of IND approvals and inform the development of effective and safe new therapies.
Focus Session

8:15 AM – 9:45 AM CEST

INSIGHTS FROM REGULATORS: LESSONS LEARNED FROM THE ISSCR’S REGULATORY LIAISON MEETINGS

Focus Session Speaker: Jennifer Moody, PhD – Danaher

Focus Session Speaker: Tenneille Ludwig, PhD – WiCell Research Institute

Focus Session Speaker: Jacqueline Barry, PhD – Cell and Gene Therapy Catapult

Focus Session Speaker: Nissim Benvenisty, MD, PhD – The Hebrew University

Focus Session Speaker: Derek Hei, PhD – Clade Therapeutics

Focus Session Speaker: Kapil Bharti, PhD – National Eye Institute; National Center for Advancing Translational Sciences, National Institutes of Health

Organized by: ISSCR Industry Committee
Human Pluripotent Stem Cell (hPSC)-derived cell therapies are now being investigated in clinical trials. Despite 26 years of rigorous basic science with hPSCs, navigating the regulatory landscape for the clinical translation of PSC-derived cell therapies remains challenging due to the complexities of cellular drug products and limited experiences reviewing and approving them. As the leading stem cell society, the ISSCR is in a unique position to share its scientific expertise with global regulators and work with agencies to facilitate improved future regulatory processes for stem cell-based therapies. In this ISSCR Industry Focus Session, the society shares important insights and feedback gleaned from its liaison meetings with regulatory agencies with our community of scientists to ameliorate their chances of IND approvals and inform the development of effective and safe new therapies.

Focus Session

PLENARY SESSION - 10:00 AM SATURDAY
10:00 AM – 11:35 AM CEST
PLENARY VI: THE CLINICAL REALITY AND PROMISE OF CELL AND GENE THERAPIES
Plenary Speaker: Catherine Priest, PhD (she/her/hers) – Neurona Therapeutics
Plenary Speaker: Robert P. Coppes, PhD (he/him/his) – University Medical Center Groningen
Plenary Speaker: Cristiana F. Pires, PharmD, PhD – Asgard Therapeutics
Speaker: Mikael Rydberg – Patient Advocate
Plenary Speaker: Michael Lai, PhD (he/him/his) – HeartWorks
Hear from invited speakers from the various realms of regenerative medicine: ESC- and iPSC-derived cell therapies, gene therapies, and in situ reprogramming.
Clinical Applications

PLENARY SESSION - 1:30 PM SATURDAY
1:30 PM – 3:35 PM CEST
PLENARY VII: AWARDS & KEYNOTE SESSION
Award Winner: Sergiu Pașca, PhD – Stanford University
Award Winner: Fiona M. Watt, DPhil FRS – EMBL-Heidelberg, Germany
Keynote Speaker: Melissa Little, AC, PhD – Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Denmark, and Murdoch Children’s Research Institute, Australia
This session is the capstone of the Annual Meeting and will include the Public Service Award presentation and lectures from the winners of the ISSCR Momentum and Achievement Awards, in addition to the Keynote Address.

ISSCR Public Service Award
Peter Andrews, BSc, DPhil, MBA, University of Sheffield, UK
Tenneille Ludwig, PhD, WiCell Stem Cell Bank, USA

ISSCR Momentum Award Lecture
Sergiu Paşca, PhD, Stanford University, USA

ISSCR Achievement Award Lecture
Fiona M. Watt, DPhil, FRS, EMBL -Heidelberg, Germany

Melissa Little, AC, PhD, Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Denmark, and Murdoch Children’s Research Institute, Australia

1:30 PM – 3:35 PM CEST

PLENARY VII: AWARDS & KEYNOTE SESSION

Award Winner: Sergiu Pașca, PhD – Stanford University

Award Winner: Fiona M. Watt, DPhil FRS – EMBL-Heidelberg, Germany

Keynote Speaker: Melissa Little, AC, PhD – Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Denmark, and Murdoch Children’s Research Institute, Australia

This session is the capstone of the Annual Meeting and will include the Public Service Award presentation and lectures from the winners of the ISSCR Momentum and Achievement Awards, in addition to the Keynote Address.

ISSCR Public Service Award
Peter Andrews, BSc, DPhil, MBA, University of Sheffield, UK
Tenneille Ludwig, PhD, WiCell Stem Cell Bank, USA

ISSCR Momentum Award Lecture
Sergiu Paşca, PhD, Stanford University, USA

ISSCR Achievement Award Lecture
Fiona M. Watt, DPhil, FRS, EMBL -Heidelberg, Germany

Melissa Little, AC, PhD, Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Denmark, and Murdoch Children’s Research Institute, Australia