THE USE OF STEM CELLS IN DISEASE MODELING I

Sponsored By 

Concurrent Speaker(s)

• 

  Sonia Gandhi, BMBCh PhD (she/her/hers)

  The Francis Crick Institute and University College London, UK
• 

  Gabsang Lee, PhD (he/him/his)

  Institute for Cell Engineering
  Johns Hopkins School of Medicine, USA

Presenting Author(s)

• 

  Sara Nolbrant, PhD

  Department of Neurology
  University of California, San Francisco, United States
• 

  Heein Song

  Internal Medicine, Nephrology
  Leiden University Medical Center, Netherlands
• 

  Meiyan Wang

  LOG-G
  Salk Institute for Biological Studies, USA

Stem cells can be derived from patients with many diseases and used as platforms for understanding molecular mechanisms underlying disease with a view to developing therapies.

Presentations:

• ADVANCED HUMAN IPSC-BASED PRECLINICAL MODEL FOR PARKINSON’S DISEASE WITH OPTOGENETIC ALPHA- SYNUCLEIN AGGREGATION
  

  Concurrent Speaker: Gabsang Lee, PhD (he/him/his) – Johns Hopkins School of Medicine
• INTERSPECIES ORGANOIDS REVEAL HUMAN-SPECIFIC MOLECULAR FEATURES OF DOPAMINERGIC NEURON DEVELOPMENT AND VULNERABILITY
  

  Presenting Author: Sara Nolbrant, PhD – University of California, San Francisco
• APOL1 RISK VARIANTS INDUCE PODOCYTE MITOCHONDRIAL DYSFUNCTION IN PATIENT-DERIVED KIDNEY ORGANOIDS
  

  Presenting Author: Heein Song – Leiden University Medical Center
• IDENTIFICATION OF TWIST1 AS A TRUE SYNTHETIC LETHAL TARGET OF TSC2-NULL NEURAL CREST CELLS THROUGH GENOME-WIDE CRISPR KNOCKOUT SCREEN.
• ASTROCYTE DIVERSITY CAPTURED IN GLIA-ENRICHED CORTICAL ORGANOID TRANSPLANTED IN MOUSE BRAIN
  

  Presenting Author: Meiyan Wang – Salk Institute for Biological Studies
• THINKING BIG TO SEE SMALL: RESOLVING PROTEINOPATHY IN PATIENT DERIVED STEM CELL MODELS OF PARKINSON’S DISEASE
  

  Concurrent Speaker: Sonia Gandhi, BMBCh PhD (she/her/hers) – The Francis Crick Institute and University College London