Innovation Showcase
CytoTronics' Pixel introduces a revolutionary method for monitoring cell activity, utilizing label-free, non-invasive live cell electrical imaging, thereby surpassing traditional optical imaging techniques. The platform uses a high-density electrode array with single cell resolution (12.5 µm) to capture over 20 functional and morphological parameters, including tissue barrier integrity, cell-surface attachment, cell flatness, and motility through unique field-based impedance measurements. To complement, electrophysiological recordings, combined with the ability to electrically stimulate cells, enables functional assessments of electrogenic cells, such as cardiomyocytes and neurons. Measurements can be taken at intervals ranging from minutes to hours, creating "electrical heat maps" and time-lapsed videos revealing the end-to-end journey of an experiment. Cell features can be assessed at the well level generating a population average, or spatial data can be used to evaluate single-cell behavior and assess heterogeneity in cells and their responses. Further insights into kinetics are derived from time-domain analyses. Assay development, initially conducted in a single plate, can seamlessly scale up to a multi-plate format without compromising time resolution or readout quality. The Pixel represents a groundbreaking tool for characterizing in vitro disease models and streamlining phenotypic screening for therapeutic interventions.