Science Spotlight

CELL POLARITY IN ORGANOID-DERIVED MODELS OF HEALTH AND DISEASE

Organized by: Georg Csukovich, University of Veterinary Medicine, Vienna

This Science Spotlight Session highlights the importance of cell polarity in organoid-based models. Cell polarity is not only crucial in the developing human body, but also for homeostasis and pathophysiological processes in the adult human body (maintenance of the stem cell niche, viral/bacterial infection of cells, etc.). Methods like reversing organoid cell polarity or generation of organoid-derived monolayers give researchers experimental control and access to polarized surfaces, but can modify the stem and differentiated cell niches. Thus, newly established organoid-based models need to be carefully evaluated beforehand to ensure meaningful outcomes. We want to discuss the different models available to probe the basolateral and apical cell surfaces and opportunities and trade-offs of controlling cell polarity in 3D models.

4:00 - 4:12 Georg Csukovich, University of Veterinary Medicine, Austria
WELCOME AND OVERVIEW

4:12 - 4:36 Sina Bartfeld, Technische Universität Berlin, Germany
CELL POLARITY AND DIFFERENTIATION IN GASTROINTESTINAL ORGANOIDS AND ORGANOID-DERIVED INFECTION MODELS

4:36 - 4:48 Lena Schorr, German Cancer Research Center, Germany
MODELLING CANCER-MICROBE INTERACTIONS WITH ORGANOIDS AND ORGAN-ON-CHIP

4:48 - 5:00 Merve Ceylan, Uppsala University, Sweden
ENHANCING INTESTINAL ADME RESEARCH USING HUMAN ENTEROIDS

5:00 - 5:30 PANEL DISCUSSION: CHALLENGES ASSOCIATED WITH EPITHELIAL POLARITY IN ORGANOID-DERIVED MODELS
Panel Moderator:
Georg Csukovich, University of Veterinary Medicine, Austria