Innovation Showcase
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Human-induced Pluripotent Stem Cell (hiPSC)-derived brain organoids offer invaluable insights into human brain development and disease mechanisms. However, existing technologies struggle to fully capture their intricate 3D functionality.
Accura-3D represents a groundbreaking microchip-based plate featuring thousands of ultrathin penetrating electrodes designed to record the inner layers of organoids. This innovation enables a non-destructive, label-free electrical recording method, akin to a "functional microscope": simply retrieve your sample from the incubator, acquire data while visualizing activity in real-time and return it. Fast and easy, it's perfect for lengthy maturation protocols, kinetic studies, or examining organoid dynamics at high resolution.
Furthermore, the design of Accura-3D facilitates the creation of microfluidic channels beneath the sample, enhancing oxygenation and compound delivery.
Powered by our advanced CorePlate™ technology, Accura-3D allows simultaneous recording from 4096 electrodes, enabling the study of network activity at single-cell resolution. This yields data at exceptional spatiotemporal resolution, markedly improving data quality and reducing experimental variability. Consequently, researchers can conduct in-depth analyses of their samples, extract functional connectivity maps, study local field potentials, and calculate over 100 different activity metrics.
At 3Brain, we are dedicated to providing researchers with the most advanced tools for advancing brain organoid research.