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Sergiu P. Pașca, PhD

Stanford University, United States

Dr Sergiu Pasca is a faculty in the Department of Psychiatry and Behavioral Sciences at Stanford University and the Uytengsu Director of the Stanford Brain Organogenesis Program. He is also a CZI Ben Barres Investigator and a NYSCF Robertson Investigator. His laboratory explores the biological underpinnings of brain disease with cellular models generated by reprogramming technologies. Dr Pasca developed some of the initial stem-cell derived models of neuropsychiatric disorders by deriving neurons from patients with autism and other developmental conditions. His laboratory used instructive signals in 3D cultures to develop self-organizing preparations known as brain spheroids or regionalized organoids, and pioneered the controlled assembly of 3D cultures to build circuits in brain assembloids. He applied these technologies to gain insights into the molecular mechanisms of genetic and environmental disorders of the developing brain. Dr Pasca was named a Visionary in Medicine and Science by New York Times and he is the recipient of the Vilcek Award for Creative Biomedical Promise (shared with Feng Zhang and Polina Anikeva), the A.E. Bennett Award in Biological Psychiatry, the MQ Fellow Award for Transforming Mental Health, the NIMH Director’s BRAINS Award, the Folch-Pi Neurochemistry Award, the ASCB Early Career Award for Cell Biology and the Daniel E. Efron Award.

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