CELLULAR PLASTICITY IN REGENERATION AND CANCER

Concurrent Speaker(s)

• 

  Elisa Laurenti, PhD (she/her/hers)

  Cambridge Stem Cell Institute, Department of Haematology
  University of Cambridge, United Kingdom
• 

  Peter Reddien, PhD

  Whitehead Institute MIT, USA

Presenting Author(s)

• 

  Swarnabh Bhattacharya, PhD

  Medical Oncology
  Dana-Farber Cancer Institute/Harvard Medical School, United States
• 

  Sandra Gomez Lopez

  Lungs for Living Research Centre, UCL Respiratory
  University College London, UK
• 

  Anupama Hemalatha, PhD

  Genetics
  Yale School of Medicine, USA
• 

  Mark Schmitt, PhD

  Institute of Pharmacology
  University of Marburg, Germany

Cell fate transitions, once thought to be irrevocable, are now known to frequently exhibit plasticity. Remarkably, even some terminally differentiated cells can regain the capacity to self-renew when challenged. This session will explore the nature of plasticity in cell fate decisions, pinpoint the contexts in which plasticity is invoked, and dissect its molecular and signaling basis.

Presentations:

• TRACKING HUMAN HAEMATOPOIETIC REGENERATION (AND LOSS OF IT) AT SINGLE CELL RESOLUTION
  

  Concurrent Speaker: Elisa Laurenti, PhD (she/her/hers) – University of Cambridge
• DIFFERENTIATED LINEAGES ARE THE CELLS-OF-ORIGIN OF COLON CANCER IN THE CONTEXT OF INFLAMMATION
  

  Presenting Author: Mark Schmitt, PhD – University of Marburg
• UNIFIED IDENTITY OF GOBLET AND PANETH CELLS AND CHROMATIN BASIS FOR INTESTINAL EPITHELIAL DIFFERENTIATION
  

  Presenting Author: Swarnabh Bhattacharya, PhD – Dana-Farber Cancer Institute/Harvard Medical School
• FROM AIRWAY BASAL CELLS TO PREINVASIVE LUNG SQUAMOUS CELL DISEASE
  

  Presenting Author: Sandra Gomez Lopez – University College London
• LIVE-IMAGING REVEALS METABOLIC REWIRING IN SKIN STEM CELLS THAT DRIVE TOLERANCE TO ONCOGENIC MUTATIONS IN VIVO BY TWO DISTINCT CELL COMPETITION STRATEGIES.
  

  Presenting Author: Anupama Hemalatha, PhD – Yale School of Medicine
• CHOICES IN REGENERATION: HOW PLANARIAN STEM CELLS CHOOSE THEIR FATE
  

  Concurrent Speaker: Peter W. Reddien, PhD – Whitehead Institute MIT