Innovation Showcase
As the landscape of organoid research continues to evolve, we explore real-world applications in disease modeling and developmental biology.
Robert Opitz, Institute of Experimental Endocrinology, will discuss using hiPSC-derived cerebral organoids as a model to study the regulatory role of thyroid hormones (TH) during early human cortex development. His team applied single-cell RNA sequencing and RNAscope™ in situ hybridization to identify TH-induced changes in specific neuronal cell types and spatial expression patterns of genes regulating cortical neurogenesis, capturing these changes with high spatial resolution.
Kai Kretzschmar, Julius-Maximilians University, will present on using organoid technology to analyze the cellular and molecular biology of oral epithelia in both steady and disease states. The complex stem cell niches and structural heterogeneity of the oral cavity have left it underexplored compared to skin and gut epithelia.
Generating robust organoid cultures relies on creating consistent and reproducible conditions. Through the provision of high-quality reagents and innovative technologies for spatial biology and automated protein analysis, Bio-Techne enables researchers to increase their culture consistency and get the most out of their precious samples.
Join this Innovation Showcase to learn more about these advancements in organoid research and get recommendations for achieving reproducible culture conditions.