Gunnar Hargus, MD, PhD

Columbia University, United States

Dr. Hargus' research focuses on pluripotent stem cells and their application in developmental biology and disease modeling with a special focus on frontotemporal dementia (FTD). Dr. Hargus and colleagues have derived induced pluripotent stem (iPS) cells from patients with FTD carrying mutations in the gene encoding the microtubule-associated protein tau as an in vitro model for FTD. These mutations lead to abundant deposition of hyperphosphorylated tau protein within neurons and glial cells in various brain regions including the frontotemporal lobes and the brain stem. Dr. Hargus' aim is to identify mechanisms that lead to neural degeneration in FTD.

Presentation(s):

• NEURONS FROM PATIENTS WITH FRONTOTEMPORAL DEMENTIA RELEASE OSTEOPONTIN AND ELICIT AN INFLAMMATORY RESPONSE

  Saturday, July 13, 2024
  9:00 AM – 9:10 AM CEST

• THE USE OF STEM CELLS IN DISEASE MODELING II

  Saturday, July 13, 2024
  8:15 AM – 9:45 AM CEST